12/3/2023 0 Comments Lama laba aafp![]() The investigators initially identified 4346 publications of which 23 and 12 met eligibility criteria for COVID-19 and long COVID, respectively. The specific endpoints of interest included sequelae of COVID-19 (defined as COVID-related new condition or chronic symptom a patient developed after resolution of acute infection (no longer than 4 weeks from symptom onset) and long COVID syndrome (defined by the persistence of symptoms, development of sequelae, and delayed or long-term complications beyond 4 weeks from the onset of COVID-19 symptoms. Time frame for the searches were December 2019–August 2020 for COVID-19 and January 2020–June 2021 for Long COVID syndrome. The J&J team considered published observational, case-control, cohort, randomized controlled, and retrospective and prospective real-world experience studies of COVID-19 infection that included at least 20 participants and reported complete data by sex. "Unfortunately, most studies did not evaluate or report granular data by sex, which limited sex-specific clinical insights that may be impacting treatment.”įocused on this goal themselves, the researchers conducted a literature review, searching 4 large databases to identify COVID-19 studies of adults aged ≥18 years who had tested positive for SARS-CoV-2. Unfortunately, most studies did not evaluate or report granular data by sex, which limited sex-specific clinical insights that may be impacting treatment.” “Therefore, differences in outcomes between females and males infected with SARS-CoV-2 could have been anticipated. “Sex differences in outcomes have been reported during previous coronavirus outbreaks,” the authors add. Their findings, the authors emphasize, highlight a critical need for sex-disaggregated research to ensure that therapies as well as public health interventions “are inclusive of and sensitive to the potential differential treatment needs of both sexes.” Men, on the other hand, were more likely to experience endocrine disorders, including diabetes and acute kidney injury (AKI). Investigators from the Johnson & Johnson Office of the Chief Medical Officer Health of Women Team, after analyzing data from approximately 1.3 million patients, found that women with long COVID presented with a range of symptoms including ear, nose, and throat issues mood, neurologic, skin, gastrointestinal, and rheumatologic disorders and fatigue. Women were found “significantly” more likely to experience long COVID than men, with odds of developing the syndrome 22% higher and the type of symptoms substantially different between the sexes, according to a new literature review published June 21, 2022, in Current Medical Research and Opinion.
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